Numerical Simulations of Structural Chromosomal Instability


  • Yuri A. Eidelman Institute of Biochemical Physics, Russian Academy of Sciences
  • Svetlana V. Slanina Institute of Biochemical Physics, Russian Academy of Sciences
  • Valentina S. Pyatenko Institute of Biochemical Physics, Russian Academy of Sciences Medical Radiological Research Center
  • Sergey G. Andreev Institute of Biochemical Physics, Russian Academy of Sciences National Research Nuclear University MEPhI



The origin of dose-response curves for radiation-induced chromosomal instability (CI) is studied using the mechanistic CI model. The model takes into account DNA damage generation and repair in the progeny of irradiated cells and cell passage through mitotic cycle. We consider the formation of DNA double-strand breaks (DSBs) de novo in the S phase, where predominantly chromatid-type aberrations are formed. Among them sister chromatid exchanges of the “isochromatid deletion” type, or “chromatid dicentrics” are of primary interest. When the cell enters mitosis, the fate of chromosomal aberrations depends on their types. Chromosomal and chromatid fragments, having entered mitosis, either are transmitted into one of the daughter cells, or are lost. A chromatid dicentric in mitosis forms an anaphase bridge. These mechanistic assumptions were used to demonstrate that the dose-response curves are closely related to the dynamic curves for CI. The principles underlying this relationship are analyzed.


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How to Cite

Eidelman, Y. A., Slanina, S. V., Pyatenko, V. S., & Andreev, S. G. (2018). Numerical Simulations of Structural Chromosomal Instability. Supercomputing Frontiers and Innovations, 5(3), 42–45.

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