Developing Quasi-Steady Model for Studying Hemostatic Response Using Supercomputer Technologies
DOI:
https://doi.org/10.14529/jsfi180406Abstract
Formation of the platelet plug represents a primary response to the vessel wall injury, but may also result in vessel occlusion. The decrease of the local blood flow due to platelet thrombus formation may lead to serious complications, such as ischemic stroke and myocardial infarction. However, mechanisms responsible for regulation of thrombus dynamics are not clear. In order to get a deeper insight into the role of blood flow and platelet interactions in the formation of the primary platelet plug we developed a particle-based model of microvascular thrombosis using quasisteady flow approximation. In order to simulate thrombus dynamics at physiologically relevant timescales of several minutes, we took advantage of the supercomputer technologies. Our in silico analysis revealed the importance of platelet size heterogeneity for describing experimental data on microvascular thrombus formation. Thus, our model represents a useful tool for the supercomputeraided computational analysis of thrombus dynamics in the microvessels on physiologically relevant timescales.
References
Belyaev, A.V., Dunster, J.L., Gibbins, J.M., Panteleev, M.A., Volpert, V.: Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones. Physics of life reviews (2018), DOI: 10.1016/j.plrev.2018.02.005
Belyaev, A.V., Panteleev, M.A., Ataullakhanov, F.I.: Threshold of Microvascular Occlusion: Injury Size Defines the Thrombosis Scenario. Biophysical Journal 109(2), 450–456 (2015), DOI: 10.1016/j.bpj.2015.06.019
Coburn, L.A., Damaraju, V.S., Dozic, S., Eskin, S.G., Cruz, M.A., McIntire, L.V.: GPIba- vWF Rolling under Shear Stress Shows Differences between Type 2B and 2M von Willebrand Disease. Biophysical Journal 100(2), 304–312 (2011), DOI: 10.1016/j.bpj.2010.11.084
Geuzaine, C., Remacle, J.F.: Gmsh: A 3-D finite element mesh generator with built-in preand post-processing facilities. International Journal for Numerical Methods in Engineering 79(11), 1309–1331 (2009), DOI: 10.1002/nme.2579
Intel Vtune Amplifier home page. https://software.intel.com/en-us/vtune, accessed: 2018-09-30
Jackson, S.P., Nesbitt, W.S., Westein, E.: Dynamics of platelet thrombus formation. Journal of Thrombosis and Haemostasis 7(s1), 17–20 (2009), DOI: 10.1111/j.1538-7836.2009.03401.x
Jackson, S.P.: Arterial thrombosisinsidious, unpredictable and deadly. Nature Medicine 17, 1423 (2011), DOI: 10.1038/nm.2515
Nguyen, T.H., Palankar, R., Bui, V.C., Medvedev, N., Greinacher, A., Delcea, M.: Rupture Forces among Human Blood Platelets at different Degrees of Activation. Scientific Reports 6, 25402 (2016), DOI: 10.1038/srep25402
OpenFOAM User Guide, Version 6, https://cfd.direct/openfoam/user-guide, accessed: 2018-09-30
Paulus, J.M.: Platelet size in man. Blood 46(3), 321–336 (1975)
Stalker, T.J., Traxler, E.A., Wu, J., Wannemacher, K.M., Cermignano, S.L., Voronov, R., Diamond, S.L., Brass, L.F.: Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network. Blood 121(10), 1875–1885 (2013), DOI: 10.1182/blood-2012-09-457739
Verlet, L.: Computer “Experiments” on Classical Fluids. I. Thermodynamical Properties of Lennard-Jones Molecules. Physical Review 159(1), 98–103 (1967), DOI: 10.1103/Phys- Rev.159.98
Woldhuis, B., Tangelder, G.J., Slaaf, D.W., Reneman, R.S.: Concentration profile of blood platelets differs in arterioles and venules. American Journal of Physiology-Heart and Circulatory Physiology 262(4), H1217–H1223 (1992), DOI: 10.1152/ajpheart.1992.262.4.H1217
Downloads
Published
How to Cite
Issue
License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-Non Commercial 3.0 License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.